Diagnostik- & Forschungsinstitut für Hygiene, Mikrobiologie und Umweltmedizin

Welcome to the website of the Bordetella research network RENOBORD (Research Network on Bordetella).

Whooping cough is a highly contagious infection of the respiratory tract caused by the bacterium Bordetella pertussis. In addition to the classic whooping cough pathogen B. pertussis, a clinical picture similar to whooping cough can also be caused by other species of the Bordetella genus.

The Bordetella research network has set itself the task of gaining a better understanding of the molecular epidemiology of these pathogens by establishing comprehensive genomic surveillance of Bordetella spp.. In close collaboration with diagnostic laboratories, clinics, outpatient facilities and the public health system, we aim to link pathogen characteristics with clinical and vaccination data. Our aim is to generate findings that support the possible optimisation of existing vaccination strategies on the one hand and the development of new approaches for the prevention and control of whooping cough on the other.

The RENOBORD team will be happy to answer any questions you may have.

Yours

Prof. Ivo Steinmetz, MD

Renobord

Core Objectives of the Network

  • Conduct comprehensive genome analyses of Bordetella species using state-of-the-art molecular biology and bioinformatics approaches.
  • Develop a centralized database linking genomic data with epidemiological information, vaccination history, and clinical outcomes.
  • Generate evidence to inform novel strategies for the prevention and control of pertussis (whooping cough).
  • Advance and optimize diagnostic methodologies for Bordetella infections.

Renoboard

Contributions from Network Participants

  • Submission of Bordetella-positive PCR samples to the study center in Graz, where isolates are obtained using optimized culture techniques for subsequent genome analysis.
  • Provision of metadata related to Bordetella-PCR-positive cases—such as clinical and epidemiological details—via the secure digital platform REDCap.
Renoboard

Benefits for Network Participants

  • Complimentary antimicrobial susceptibility testing of Bordetella strains isolated from your PCR-positive samples.
  • Access to information on genomic variations identified in the submitted strains.
  • Insights into potential shifts in the composition of the local Bordetella population.
  • Opportunity to co-author scientific publications based on your contributions.

Join the Network

Please contact Prof. Ivo Steinmetz for initial information.

Depending on your location, a data transfer agreement between your institution and the Medical University of Graz may be required. We aim to make this process as straightforward as possible and look forward to welcoming you as an active member of the RENOBORD research network.

Publikationen

Publications

  • Schönfeld V, Schlaberg J, Steinmetz I, Rau C. Keuchhusten: Die aktuelle Epidemiologie in Deutschland. Epid Bull 2024; 48:3-7 | DOI 10.25646/12936
  • Wagner GE, Dabernig-Heinz J, Lipp M, Cabal A, Simantzik J, Kohl M, Scheiber M, Lichtenegger S, Ehricht R, Leitner E, Ruppitsch W, Steinmetz I. Real-Time Nanopore Q20+ Sequencing Enables Extremely Fast and Accurate Core Genome MLST Typing and Democratizes Access to High-Resolution Bacterial Patho-gen Surveillance. J Clin Microbiol 2023; 61(4): e0163122 | DOI 10.1128/jcm.01631-22.
  • Schönfeld V, Heininger U, Littmann M, Steinmetz I, Matysiak-Klose D: Aktuelle Epidemiologie von Bor-detella parapertussis Infektionen in Deutschland. Epid Bull 2023; 33:3-14 | DOI 10.25646/11681.
  • Cabal A, Schmid D, Hell M, Chakeri A, Mustafa-Korninger E, Wojna A, Stöger A, Möst J, Leitner E, Hyden P, Rattei T, Habington A, Wiedermann U, Allerberger F, Ruppitsch W. Isolate-Based Surveillance of Bordetella pertussis, Austria, 2018–2020. Emerg Infect Dis 2021 ; 27(3): 862–871 | DOI 10.3201/eid2703.202314.

RENOBORD Team

Members

Contact

Ivo Steinmetz 
T: +43 316 385 73700